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The human intrauterine environment in the presence of a progesterone-releasing device has been studied. Drugs from this class can cause serious side effects such as heart disease (including heart attack and heart failure), formation of blood-filled cysts or tumors in the liver, water retention (with swelling of ankles and feet, shortness of breath, and weight gain), kidney disease, stroke, mental health problems (including anxiety, depression, anger, trouble sleeping, abnormal drug-seeking behaviour), nausea, vomiting, headache, change in sexual interest, acne, high blood pressure, breathing problems, jaundice, high blood calcium levels (with vomiting, stomach pain, increased thirst or urination, muscle pain or weakness, joint pain), high blood fat levels, and allergic reactions (with rash, swelling of face, tongue, throat, and difficulty breathing).
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