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Do not take a double dose to make up for a forgotten one. Researchers have found that high-dose steroids such as prednisone, when used to treat systemic lupus erythematosus (SLE), increased the risk of organ damage, according to a report in MedPage Today. In any case, although statistically significant, the magnitude of these age-related changes was less than might be expected. When cortisone was first synthesized in the 1940s, it required the bile of 2,500 cows as a starting material, before a complicated 36 step chemical process was applied to produce 15 milligrams of cortisone (which is only approximately.

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